Lucia R Languino
Professor of Cancer Biology
Thomas Jefferson University
Dr.Lucia R.Languino is currently Professor of Cancer Biology and Radiation Oncology, Sidney Kimmel Cancer Center, at Thomas Jefferson University, Philadelphia, Pennsylvania. For more than twenty years, she has studied the mechanisms of prostate cancer progression and has described the role of integrin receptors, membrane and cytoskeletal dynamics, as well as intracellular signaling in prostate cancer migration, invasion and metastatic dissemination, in vivo. Dr. Languino has been recognized for using a multidisciplinary approach that combines molecular and cellular biology, biochemistry, mouse genetics and developmental therapeutics. Through the publication of more than 100 papers and review articles, she has demonstrated that integrins are valid therapeutic targets in prostate cancer and support growth factor receptor activities. Recently, Dr. Languino’s studies have focused on the composition and role of exosomes in prostate cancer metastasis and resistance to radiation therapy. Although mechanistic in nature, her studies combine a strong emphasis on disease-relevance, focused on the identification and preclinical characterization of novel molecular targets suitable for therapeutic intervention in patients with advanced and metastatic disease.
Dr. Languino's research interests focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells