Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

Vivek M. Rangnekar

Vivek M. Rangnekar

Professor and Alfred Cohen Chair in Oncology Research
Associate Director, Markey Cancer Center
USA

Biography

B.S., University of Bombay, 1976 •M.S., University of Bombay, 1979 •Ph.D., University of Bombay, 1983 •Post-doctoral Training, University of Chicago 1983-1986

Research Interest

Vivek M. Rangnekar’s laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes, in an effort to tilt the balance in favor of tumor suppressor function. The strategy is to utilize the inherent strengths of the tumor against itself, to specifically target cell survival mechanisms that are common to diverse cancers, while leaving the normal host cells unharmed. The multi-faceted tumor suppressor protein Par-4/PAWR, originally identified by Dr. Rangnekar in 1993, serves as a paradigm for such studies. Interestingly, up-regulation of Par-4 protein induces apoptotic death specifically in cancer cells, and its absence leads to tumor growth. Par-4 induces apoptosis intracellularly acting in the cytoplasm or nucleus, or extracellularly via its cell surface receptor GRP78. Dr. Rangnekar’s team is now studying novel Par-4 secretagogues that can cause elevated secretion of Par-4 for inhibition of primary and metastatic tumors.